Harbour BioMed and BioMap Jointly Initiate MegaStream TechBio: A Leading Global Drug Development Platform Joins Forces with Premier Life Science Foundation Models to Set New Benchmarks for AI-Driven Complex Biologics R&D

Under the strategic collaboration framework, the two companies will jointly launch MegaStream TechBio, a next-generation AI-native pipeline company targeting global markets.

MegaStream will integrate a proprietary ecosystem of exclusive datasets × purpose-built large models × large-scale innovative pipeline portfolio into an AI-powered R&D engine. This engine is enabled by an advanced integrated intelligent dry–wet closed loop discovery laboratory, paired with a partner-tailored, multimodal and multi-objective generative large model. Focused on addressing critical unmet clinical needs across cardiovascular, renal, oncology and anti-aging areas, MegaStream prioritizes First-in-Class (FIC) and Best-in-Class (BIC) assets as its core development benchmarks. The company will systematically advance a broad portfolio of differentiated complex biologics into clinical-stage development at scale, aiming to emerge as the world's leading AI-native complex biologics company.

As the lead founding partner, Harbour BioMed will grant access to MegaStream with its unique fully human antibody platform, in-depth target biology know-how, and global clinical development capabilities. BioMap, as co-founding partner, will contribute foundational AI technology, model engineering, and intelligent R&D capabilities to accelerate pipeline development. MegaStream's initial pipeline will consist of AI-identified drug candidates from the parties' earlier collaborations, as well as newly launched AI-driven discovery programs. The founding parties will be entitled to potential upfront payments, success-based milestones, and royalty sharing in accordance with industry practice. In addition, MegaStream's core management team will be composed of seasoned executives from multinational biopharmaceutical companies and leading experts in artificial intelligence, with key appointments currently underway.

As Co-founding Partners of MegaStream, Harbour BioMed and BioMap will jointly advance three core strategic pillars:

I. Build a World-Leading Proprietary AIDD Infrastructure Platform — Defining the Next-Generation Engineering Paradigm for Complex Biologics

Harbour BioMed and BioMap will build a globally leading AI-driven complex biologics AIDD infrastructure platform for MegaStream, powered by BioMap's premier life science foundation models, xTrimo, and the massive, high-quality datasets generated by Harbour BioMed's proprietary Harbour Mice® fully human antibody platform.

This strategic alliance sees BioMap leverage its life science foundation models alongside Harbour BioMed's high-quality full datasets. Performing systematic training, optimization and iteration tailored to the unique traits of complex biologics — which differ markedly from standard proteins and antibodies — the two sides have built a dedicated, self-evolving MegaStream large model. As the company's AI backbone, this model will be deeply optimized for next-generation complex biologic modalities—including multispecific antibodies, XDC conjugates, in vivo CAR-T, and inhaled/oral biologics—delivering robust performance advantages and enabling end-to-end AI-driven design, from sequence generation to developability optimization.

II. Build a Next-Generation Integrated Dry-wet Closed Loop Discovery Laboratory — Enabling Efficient Validation and Continuous Data Accumulation for AI-Native Molecules

Leveraging the MegaStream large model, the two companies will integrate Harbour BioMed's extensive proprietary experimental capabilities with BioMap's expertise in automated discovery orchestration, high-throughput data analysis, and model iteration—delivered through the BioMap OS discovery platform—to construct a next-generation intelligent high-throughput dry–wet discovery laboratory.

Tailored to the training and validation of multi-objective biological parameter models for complex biologics, as well as ongoing data accumulation and model iteration across the drug R&D lifecycle, the laboratory will establish a world-leading intelligent control hub and integrated experimental capabilities. It will achieve four core breakthroughs: fully intelligent orchestration, high-performance experimental validation, comprehensive automated data capture and analysis, and highly efficient AI modeling and model evolution—forming a complete Design-Build-Test-Learn (DBTL) automated closed loop.

Once operational, this AI-native laboratory is projected to deliver greater than 500% efficiency gains over previous-generation platforms, dramatically accelerating complex biologics discovery and iteration. Data accumulation efficiency will increase by more than 10-fold, with the system expected to generate over 5 petabytes of high-quality, AI-ready life science data within five years—continuously fueling rapid AI model evolution.

III. Scale Up Next-Generation R&D Pipelines: End-to-End Loop from AI Creation to Clinical Value

Harbour BioMed and BioMap's first AI+ biotech-driven FIC pipeline collaboration dates back to 2021, encompassing property prediction, optimization, and generative design across more than 10 pipeline programs. Powered by the newly established AI complex biologics platform, FIC/BIC discovery capabilities will be substantially enhanced—enabling Harbour BioMed and MegaStream to advance hundreds of innovative programs in parallel.

By replacing traditional repetitive screening with AI model predictions and targeted, high-precision validation, and leveraging the power of generative AI models, the platform will produce pipeline molecules with superior performance metrics, more comprehensive multi-objective optimization, and more precise programmable control. In the coming years, the two companies will accelerate the clinical translation of both existing assets and newly initiated FIC/BIC programs—building an industry-leading, fully integrated value chain from AI-powered discovery to clinical realization.

Dr. Jingsong Wang, Founder, Chairman, and Chief Executive Officer of Harbour BioMed and Chairman of MegaStream TechBio, said: "This partnership opens a new chapter in biopharmaceutical innovation. We bring over a decade of world-class, proprietary antibody data from our Harbour Mice® platform. BioMap brings a 268-billion-parameter life science AI engine. Together, we are closing the loop from AI molecular design to clinical development—systematically raising the speed and success rate of next-generation complex biologics discovery. MegaStream will complete its corporate setup and launch its first pipeline portfolios with proven execution efficiency. We also look forward to joining hands with long-term global partners and top-tier investors to unlock new opportunities across the industry."

Mr. Wei Liu, Co-Founder and Chief Executive Officer of BioMap, said: "BioMap was built to push AI to the frontier of biology—to give drug developers a platform capable of running generative, multi-objective discovery at scale. Harbour BioMed's Harbour Mice® and Hu-mAtrIx™ platforms are the gold standard in data-rich antibody engineering. By integrating their unique data assets and deep drug development expertise with our xTrimo foundation models, we are building something the industry has never seen: a true generative AI infrastructure for biopharma. This sets a new paradigm for how AI can power drug discovery across the entire field."

About Harbour BioMed

Harbour BioMed (HKEX: 02142) is a global biopharmaceutical company committed to the discovery and development of novel antibody therapeutics in immunology, oncology and other areas. The Company is building a robust portfolio and differentiated pipeline through internal R&D capability, strategic global collaborations in co-discovery and co-development, and selective acquisitions.

Our proprietary antibody technology platform, Harbour Mice®, generates fully human monoclonal antibodies in both the conventional two heavy and two light chain (H2L2) format and the heavy chain-only (HCAb) format. Building upon HCAb antibodies, the HCAb-based immune cell engagers (HBICE®) bispecific antibody technology enables tumor-killing effects that traditional combination therapies cannot achieve. The HCAb-based Antibody Plus technology (HCAb PLUS™) provides comprehensive modality solutions for the development of innovative multi-specific medicines in different disease areas. Additionally, building upon the Harbour Mice® platform, Harbour BioMed launched its first fully human Generative AI HCAb Model powered by its Hu-mAtrIx™ AI platform, accelerating the development of innovative therapies.

By integrating Harbour Mice®, HBICE®, HCAb PLUS™, a single B-cell cloning platform and AI technologies, Harbour BioMed has built a highly efficient and distinctive antibody discovery engine for developing next-generation therapeutic antibodies. For more information, please visit www.harbourbiomed.com.

About BioMap

BioMap is a global leader in AI foundation models for life sciences, dedicated to building next-generation AI infrastructure to accelerate scientific discovery across the industry.

Our proprietary 268-billion-parameter life sciences foundation model family, xTrimo, learns the underlying rules governing genes, proteins, cells, and biological systems, delivering highly accurate AI-driven predictions. It has achieved state-of-the-art (SOTA) performance across more than 300 predictive tasks spanning over 20 life science subfields, and was awarded the championship title at the first global Virtual Cell Challenge.

Built upon our foundation model, our product BioMap OS is an AI-powered life sciences discovery system that enables users to establish systematic AI capabilities. Through AI-driven dry–wet closed-loop discovery, it supports data insights, parameter optimization, and de novo design, while empowering users to accumulate proprietary data and train their own AI models, continuously enhancing their AI capabilities over time. BioMap currently supports over 800 institutional users worldwide, spanning multiple verticals including antibody and protein, innovative therapies and precision medicine, synthetic biology, and frontier scientific research. For more information, please visit www.biomap.com.

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